The Effect and Mechanism of MMP-9 in Inducing Atherosclerosis

Majianhua

Status

Unknown

Conditions

Type 2 Diabetes

Treatments

Diagnostic Test: diagnosed as type 2 diabetes without atherosclerosis

Diagnostic Test: people without type 2 diabetes or atherosclerosis

Diagnostic Test: diagnosed as type 2 diabetes with atherosclerosis

Study type

Observational

Funder types

Other

Identifiers

KY20200320-01

Details and patient eligibility

About

The study will assess the serum expression of MMP-9 in normal people, type 2 diabetic patients and type 2 diabetic patients with atherosclerosis.

Enrollment

180 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

volunteer to participate and be able to sign informed consent prior to the trial.
patients with type 2 diabetes, aged 18-60 years old, meeting WHO1999 diagnostic criteria, have not used any drugs.
The patients have completed carotid ultrasound during hospitalization.

Exclusion criteria

patients with any antidiabetic drugs.
impaired liver and kidney function with ALT 2.5 times higher than the upper limit of normal value; Serum creatinine was 1.3 times higher than the upper limit of normal.
drug abuse and alcohol dependence in the past 5 years.
systemic hormone therapy was used in the last three months.
patients with infection and stress within 4 weeks.
any other obvious conditions or associated diseases determined by the researcher: such as severe cardiopulmonary diseases, endocrine diseases, neurological diseases, tumors and other diseases, other pancreatic diseases, history of mental diseases.