The Effect and Mechanism of MMP-9 in Inducing Atherosclerosis

M

Majianhua

Status

Unknown

Conditions

Type 2 Diabetes

Treatments

Diagnostic Test: diagnosed as type 2 diabetes without atherosclerosis
Diagnostic Test: people without type 2 diabetes or atherosclerosis
Diagnostic Test: diagnosed as type 2 diabetes with atherosclerosis

Study type

Observational

Funder types

Other

Identifiers

NCT04424706
KY20200320-01

Details and patient eligibility

About

The study will assess the serum expression of MMP-9 in normal people, type 2 diabetic patients and type 2 diabetic patients with atherosclerosis.

Enrollment

180 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • volunteer to participate and be able to sign informed consent prior to the trial.
  • patients with type 2 diabetes, aged 18-60 years old, meeting WHO1999 diagnostic criteria, have not used any drugs.
  • The patients have completed carotid ultrasound during hospitalization.

Exclusion criteria

  • patients with any antidiabetic drugs.
  • impaired liver and kidney function with ALT 2.5 times higher than the upper limit of normal value; Serum creatinine was 1.3 times higher than the upper limit of normal.
  • drug abuse and alcohol dependence in the past 5 years.
  • systemic hormone therapy was used in the last three months.
  • patients with infection and stress within 4 weeks.
  • any other obvious conditions or associated diseases determined by the researcher: such as severe cardiopulmonary diseases, endocrine diseases, neurological diseases, tumors and other diseases, other pancreatic diseases, history of mental diseases.

Trial design

180 participants in 3 patient groups

Normal people
Description:
No diabetes and atherosclerosis
Treatment:
Diagnostic Test: people without type 2 diabetes or atherosclerosis
type 2 diabetes mellitus without atherosclerosis
Description:
Newly diagnosed type 2 diabetes without atherosclerosis
Treatment:
Diagnostic Test: diagnosed as type 2 diabetes without atherosclerosis
type 2 diabetes mellitus with atherosclerosis
Description:
Newly diagnosed type 2 diabetes with atherosclerosis
Treatment:
Diagnostic Test: diagnosed as type 2 diabetes with atherosclerosis

Trial contacts and locations

1

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Central trial contact

Jianhua Ma, Doctor

Data sourced from clinicaltrials.gov

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