The Effect and Mechanisms of the Second-meal Phenomenon in Type 2 Diabetic Patients

The Catholic University of Korea

Status: Completed

Conditions: Type 2 Diabetes

Study type: Observational

Funder types: Other

Identifiers

NCT01127997

VC10EISI0007

Details and patient eligibility

About

Second-meal phenomenon denotes the effect of a prior meal in decreasing the rise in blood glucose after a subsequent meal. This phenomenon occurs in normal subjects while it is not clear whether it is also observed in type 2 diabetic patients. This study aims to define whether the second-meal phenomenon occurs in type 2 diabetic patients. We will also seek for the mechanism.

Enrollment: 12 estimated patients

Sex: All

Ages: 35 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age 35-70
• HbA1c 6-8%
• DM duration less than 5 yrs

Exclusion criteria

• type 1 DM, secondary DM, gestational DM
• patients using insulin, TZDs
• patients using corticosteroid, herb medication or other medications affecting glucose tolerance
• renal dysfunction (Cr > 1.5mg/dL)
• hepatic dysfunction (LFT > x 3UNL)
• anemia (Hg < 10g/dL)
• ischemic heart disease, congestive heart failure
• severe diabetic complication (CRF, CVA, PDR, gastroparesis)
• infectious disease
• malignancy
• pregnant women

Trial design

12 participants in 2 patient groups

study A

Description:

post-breakfast meal tolerance test + post-lunch meal tolerance test

study B

Description:

fasting + post-lunch meal tolerance test