The Effect of 10-Week Exercise Training on Children With Asthma

University of California Irvine (UCI)

Status: Withdrawn

Conditions: Asthma in Children

Treatments: Other: Exercise Training

Study type: Interventional

Funder types: Other

Identifiers

NCT03716219

2012-9253

Details and patient eligibility

About

The goal of this research is to determine whether 10-weeks of exercise training can benefit asthmatic children and young adults with a history of exercise-induced bronchoconstriction (EIB). The investigators will also study an exciting newly discovered aspect of gene expression regulation in the white blood cells known as epigenetics: a process that takes place when genomic changes happen as a result of exposure to the environment. This study is based on emerging exciting new data from this and other laboratories demonstrating that (a) white blood cells play an important role in bronchoconstriction in children, (b) gene and cytokine expression in circulating white blood cells are abnormal in asthma and (c) brief exercise may change genomic and inflammatory- profiles of these cells.Physical activity is an essential component of growth and health in children, thus, this research will lead to improved clinical uses of exercise as preventive and adjunctive therapy in the current epidemic of childhood asthma

Sex: All

Ages: 8 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Good health
• Physical activity
• No evidence of disease or disability
• Diagnosed with persistent asthma (asthma subjects)
• BMI<95 percentile

Exclusion criteria

• Use of illegal drugs or alcohol
• Very high physical fitness
• Pregnancy
• More than two asthma attack per week (asthma subjects)

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

0 participants in 2 patient groups

Healthy Subjects

Other group

Description:

Healthy control group which received the same exercise training intervention as the experimental group

Treatment:

Other: Exercise Training

Subjects with Asthma

Experimental group

Description:

Subjects with asthma who received exercise training

Treatment:

Other: Exercise Training