The Effect of a Blue Light Filtering IOL

Showa University

Status: Completed

Conditions: to Compare the Effect of Two Types of IOLs; on the Incidence of Cystoid Macular Edema; After Cataract Surgery

Treatments: Procedure: intraocular lens implantation

Study type: Interventional

Funder types: Other

Identifiers

NCT00571831

Toshi-1

showa-IRB-02503

Details and patient eligibility

About

To compare the effect on blood retinal barrier disruption 3 and 12 months after implantation of either a blue light filtering intraocular lens(blue-filtering IOL) or an ultraviolet light filtering intraocular lens(UV-filtering IOL).

Full description

The following parameters were measured for evaluation of blood retinal barrier disruption.

• the incidence of macular leakage by fluorescence angiography (FA)
• the mean fluorescein concentration in the vitreous by fluorophotometry (VFP)
• the thickness of the macula by optical coherence tomography (OCT)

Results

• the incidence fo macular leakage decreased significantly from 24%(3 months) to 5% (12 months) in the blue-filtering IOL group (P<0.05), and was significantly lower compared with the UV-filtering IOL group at 12 months.
• the VFP significantly decreased in both group from 3 to 12 months.
• the OCT decreased from 175 (3 months) to 166 um (12 months) in the blue- filtering IOL group.

Enrollment: 50 patients

Sex: All

Ages: 50 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• cataract patients
• All eligible for intraocular lens implantation

Exclusion criteria

• Patients had undergone an intraocular operation
• Patients had hypertensive retinopathy
• Patients had diabetic retinopathy
• Patients had ange-related macular degeneration
• no observable fundus
• The cataract operation was more than 30 minutes in duration

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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50 participants in 1 patient group

letter

No Intervention group

Description:

a blue-filtering IOL an UV-filtering IOL

Treatment:

Procedure: intraocular lens implantation