The Effect of a Ketone Drink on Blood Glucose Levels in People With Type 2 Diabetes

University of Exeter

Status: Completed

Conditions: Type 2 Diabetes

Treatments: Dietary Supplement: Ketone supplement; Dietary Supplement: Placebo supplement

Study type: Interventional

Funder types: Other

Identifiers

NCT06324669

4765060

Details and patient eligibility

About

Ketones are naturally produced by our body and can affect our blood sugar levels. Ketones could be important in the treatment of type 2 diabetes (T2D). The purpose of this research is to determine if a ketone drink can lower blood sugar in people with T2D following a meal. This research will provide new knowledge about the regulation of blood sugar. This may also inform if ketone drinks could be used as a treatment for T2D.

Enrollment: 15 patients

Sex: All

Ages: 41 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Aged 41-70 years old
2. Body mass index 27-40 mg/m²
3. Type 2 diagnosis for more than 1 year
4. HbA1c >6%

Exclusion criteria

1. Currently following ketogenic diet
2. Use of insulin
3. HbA1c >10%
4. Recent weight loss (>5kg in 6 months)
5. Recent eGFR <30mL/min
6. Heart failure
7. Substance abuse
8. Cancer
9. Myocardial infarction within 6 months
10. Pregnancy or consideration of
11. Use of antipsychotic drugs

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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15 participants in 2 patient groups, including a placebo group

Ketone supplementation

Experimental group

Description:

100 mL flavoured drink containing 0.3 g/kg ketone monoester ((R)-3-hydroxybutyl (R)-3-hydroxybutyrate; ΔG®, University of Oxford; https://www.deltagketones.com)

Treatment:

Dietary Supplement: Ketone supplement

Placebo

Placebo Comparator group

Description:

Placebo with stevia and bitter agent to flavour match

Treatment:

Dietary Supplement: Placebo supplement