The Effect of a Low Glycemic Load Diet on Hormonal Markers Associated With Acne

New York University (NYU)

Status: Completed

Conditions: Acne Vulgaris

Treatments: Other: Low Glycemic Load Diet; Other: Usual Eating Plan

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT02913001

New York University

Details and patient eligibility

About

This randomized controlled trial will examine changes in some hormonal markers associated with acne among adults with moderate/severe acne randomized to a low glycemic index and glycemic load diet or usual eating plan for two weeks.

Full description

The objectives of this randomized controlled trial are to investigate the impact of a low glycemic index/load eating plan on endocrine aspects of acne. Specifically, this study will examine changes in blood biochemical markers of acne among adults with acne following a modified carbohydrate (low glycemic index/load) eating plan or their usual eating plan for two weeks. An external sponsor, Nutrisystem®, will provide some low glycemic index/load foods to the study participants randomized to the intervention group for two weeks. Study outcomes include changes in glucose, insulin, insulin resistance, insulin-like growth factor-1, and insulin-like growth factor binding protein-3 concentrations.

Enrollment: 97 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Body mass index (BMI) ≥18.5 or <30.0 kg/m2
• History of moderate or severe facial acne for at least 6 months
• Able to read and speak the English language

Exclusion criteria

• > 10% weight change within the last 6 months
• Taking medications known to alter blood glucose or insulin concentrations
• Medical history of polycystic ovarian syndrome, type 1 diabetes, type 2 diabetes, or pre diabetes
• Low carbohydrate (<45% of total energy from carbohydrate), glycemic index, or glycemic load diet
• Female participants that are pregnant or lactating or were pregnant or lactating within the last year
• Current use of a pacemaker or other battery operated implant
• Facial hair that would make it difficult for a health care provider to assess facial acne.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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97 participants in 2 patient groups

Low Glycemic Load Diet

Experimental group

Description:

Participants received a diet education to follow a low glycemic load diet and received some low glycemic load staple foods.

Treatment:

Other: Low Glycemic Load Diet

Usual Eating Plan

Active Comparator group

Description:

Participants received a diet education to continue with their usual diet.

Treatment:

Other: Usual Eating Plan