The Effect of a Retrofit Particle Trap on the Vascular Effects of Diesel Exhaust Inhalation

University of Edinburgh

Status: Completed

Conditions: Heart Disease

Treatments: Procedure: Forearm Venous Occlusion Plethysmography

Study type: Interventional

Funder types: Other

Identifiers

NCT00745446

VOLVO 3ARM

Details and patient eligibility

About

The purpose of this study is to determine whether a retrofit particle trap can reduce the adverse vascular responses to diesel exhaust inhalation

Full description

18 subjects healthy male volunteers will be recruited at Umeå University. In a randomised, double blind 3 way crossover trial, subjects will be exposed to filtered air, diesel exhaust (300mcg/m3) or filtered diesel exhaust for 1 hour during intermittent exercise.

2 hours following the exposure, thrombogenicity will be assessed using the Badimon chamber - an ex-vivo model of thrombosis formed under constant flow conditions.

Forearm blood flow in response to infused intra-brachial vasodilators will be measured using venous occlusion plethysmography 6 hours after the exposure.

Arterial stiffness will be measured using peripheral arterial applanation tonometry in the hour post-exposure.

Blood samples will be collected at timepoints over the 24 hours after exposure.

Enrollment: 18 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy male volunteers

Exclusion criteria

• Intercurrent illness
• Smoking
• Significant occupational exposure to air pollution
• Regular medication usage

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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18 participants in 3 patient groups

1

Experimental group

Description:

1 hour exposure to filtered air

Treatment:

Procedure: Forearm Venous Occlusion Plethysmography

2

Experimental group

Description:

1 hour exposure to diesel exhaust (300mcg/m3)

Treatment:

Procedure: Forearm Venous Occlusion Plethysmography

3

Experimental group

Description:

1 hour exposure to filtered diesel exhaust

Treatment:

Procedure: Forearm Venous Occlusion Plethysmography