The Effect of Acute Exogenous Oral Ketone Supplementation on Immune Cells Function and Immune Cells Histone Β-hydroxybutyrylation (Acute_Ketone)

University of British Columbia

Status: Enrolling

Conditions: Histone Deacetylase (HDAC) Activity; Immune Functions; Ketosis, Metabolic

Treatments: Dietary Supplement: Ketone Monoester (KE)

Study type: Interventional

Funder types: Other

Identifiers

NCT06590623

H24-02548

Details and patient eligibility

About

To conduct a single-arm pilot study to determine how acute ingestion of an exogenous ketone monoester supplement alters the histone lysine β-hydroxybutyrylation and immune function in healthy human monocytes and lymphocytes.

Enrollment: 12 estimated patients

Sex: All

Ages: 19+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Over the age of 19
• Able to fast overnight

Exclusion criteria

• Being a competitive endurance athlete.
• Following a ketogenic diet, low-calorie diet, periodic fasting regimen, or regularly consuming ketogenic supplements.
• Being unable to travel to and from the university
• Being pregnant.
• Having been diagnosed with a chronic disorder of glucose or fat metabolism, including type 2 diabetes, chronic pancreatitis, or gallbladder disease
• Being unable to read or communicate in English.

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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12 participants in 1 patient group

exogenous ketone supplement

Experimental group

Description:

Participants will consume a ketone monoester supplement (KetoneAid KE4) at a dose of 0.75 g/kg of body weight.

Treatment:

Dietary Supplement: Ketone Monoester (KE)