The Effect of Acute Ketone Monoester Supplementation on Glucose Oxidation During Exercise (KETONE)

Maastricht University Medical Centre (MUMC)

Status: Enrolling

Conditions: Exercise Metabolism

Treatments: Dietary Supplement: CHO+PLACEBO; Dietary Supplement: CHO+KETONE

Study type: Interventional

Funder types: Other

Identifiers

NCT06746805

METC 23-001

Details and patient eligibility

About

The purpose of this study is to examine the effect of exogenous ketone body supplementation on carbohydrate metabolism during exercise. In a randomized, crossover, and double-blind study, 20 endurance trained adult males and females aged 18-50 years, will ingest carbohydrates with either a ketone monoester supplement before and throughout a 3-hour exercise session or carbohydrates with a flavour-matched ketone-free placebo. The main aim of this study is to compare the exogenous carbohydrate oxidation rates during exercise between the ketone monoester and placebo conditions.

Enrollment: 27 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18-50 years of age
• Trained cyclist/triathlete (VO2peak > 55 ml/kg/min for males and >48 ml/mg/min for females)
• Healthy as per medical history and investigator's/physician's judgement
• Having given written informed consent

Exclusion criteria

• Use of medication that could impact study outcomes and/or interfere with the expected mechanism of action of ketone supplements (e.g. Chronic use of gastric acid suppressing medication, statins, corticosteroids)
• Smoking
• Diagnosed acute or chronic medical conditions that, in the opinion of the investigator, could impact study outcomes (e.g. Diabetes mellitus)
• Diagnosed musculoskeletal disorders
• Adhering to a carbohydrate restrictive diet
• Participation in another study at the same time
• Blood donation in the 2 months before the first experimental trial
• Plasma donation in the 2 weeks before the first experimental trial
• Males: VO2peak <55 ml/min/kg body mass
• Females: VO2peak <48 ml/min/kg body mass
• Females: pregnancy

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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27 participants in 2 patient groups, including a placebo group

CHO+KETONE

Experimental group

Description:

Interventional drink with glucose + ketone monoester

Treatment:

Dietary Supplement: CHO+KETONE

CHO+PLACEBO

Placebo Comparator group

Description:

Placebo drink with glucose + placebo

Treatment:

Dietary Supplement: CHO+PLACEBO