The Effect of Acute Mild Dehydration on Blood Pressure Control

University of Delaware

Status: Completed

Conditions: Mild Dehydration

Treatments: Other: Normal hydration; Other: Dehydration

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT03560869

R01HL128388 (U.S. NIH Grant/Contract)

1097747

5P20GM113125 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The goal of this project is determine how acute mild dehydration impacts blood pressure control at rest and during static exercise. This protocol will test healthy young and older adults in a normally hydrated and dehydrated condition.

Full description

The purpose of this project is determine how acute mild dehydration impacts blood pressure control at rest and during static exercise. Additionally, we will determine whether or not the sympathetic nervous system has a role in mediating blood pressure control at rest and during static exercise. This protocol will test healthy young and older adults in a normally hydrated and dehydrated condition. This will allow for a within participant comparison. Additionally, we will later determine if age alters blood pressure control at rest or during static exercise.

Enrollment: 35 patients

Sex: All

Ages: 20 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria (Young):

• age: 20-35 years old

Exclusion Criteria (Young):

• high blood pressure (>140/90 mmHg)
• history of cardiovascular disease
• history of cancer
• history of diabetes
• history of kidney disease
• obesity (BMI > 30 kg/m2)
• smoking or tobacco use
• current pregnancy
• nursing mothers
• communication barriers

Inclusion Criteria (Older):

• age: 60-75 years old
• ECG within normal limits
• screening blood panel within normal limits

Exclusion Criteria (Older):

• high blood pressure (>140/90 mmHg)
• history of cardiovascular disease
• history of cancer
• history of diabetes
• history of kidney disease
• obesity (BMI > 30 kg/m2)
• smoking or tobacco use
• current pregnancy
• nursing mothers
• communication barriers

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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35 participants in 2 patient groups

Normal hydration then dehydration

Experimental group

Description:

Participants will consume water to maintain proper hydration for three days prior to testing (visit 1). Seven to 60 days later, participants will reduce water intake over three days and abstain from any water for the final 16 hours prior to testing (visit 2).

Treatment:

Other: Normal hydration

Other: Dehydration

Dehydration than normal hydration

Experimental group

Description:

Participants will reduce water intake over three days and abstain from any water for the final 16 hours prior to testing (visit 1). Seven to 60 days later, participants will consume water to maintain proper hydration for three days prior to testing (visit 2).

Treatment:

Other: Normal hydration

Other: Dehydration