The Effect of Adding Either Propofol or Ketamine to Magnesium and Lidocaine Infusions in Nasal Surgeries.

Ain Shams University

Status and phase: Enrolling; Phase 3; Phase 2

Conditions: Intraoperative Bleeding

Treatments: Drug: Intravenous infusion of ketamine, lidocaine, Magnesium sulfate; Drug: Intravenous Infusion of propofol, lidocaine, Magnesium sulfate; Drug: Intravenous infusion of dexmedetomidine, lidocaine, Magnesium sulfate

Study type: Interventional

Funder types: Other

Identifiers

NCT06427707

FMASU R84/2024

Details and patient eligibility

About

Nasal surgeries are common day case procedures. Although surgical complications are rare, bleeding decreases surgical field visibility and may cause vascular, orbital or intracranial complications in addition to failure of procedure. So, it is crucial to maintain hypotensive anaesthesia to optimize the surgical field.

Full description

In this study the investigators compare the effect of; propofol- lidocaine-magnesium and ketamine- lidocaine- magnesium infusions to dexmedetomidine- lidocaine- magnesium infusion on surgical field quality, intraoperative haemodynamics, surgical time, recovery time, sedation score, time to first rescue analgesic and incidence of PONV in patients undergoing nasal surgeries

Enrollment: 90 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA I-II,
• scheduled for elective nasal surgery

Exclusion criteria

• Patients with uncontrolled hypertension.
• Patients with cardiac disease.
• Patients with renal, hepatic or cerebral insufficiency.
• Patients with coagulopathy or receiving drugs influencing blood coagulation.
• Anaemia, haemoglobinopathies or polycythemia.
• Pregnancy.
• Patients with known sensitivity to any of the study drug.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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90 participants in 3 patient groups

Group PLM (propofol-lidocaine-magnesium)

Active Comparator group

Description:

intravenous infusion of propofol, lidocaine and magnesium sulfate.

Treatment:

Drug: Intravenous Infusion of propofol, lidocaine, Magnesium sulfate

Group KLM (ketamine-lidocaine-magnesium)

Active Comparator group

Description:

intravenous infusion of Ketamine, lidocaine and magnesium sulfate

Treatment:

Drug: Intravenous infusion of ketamine, lidocaine, Magnesium sulfate

Group DLM (Dexmeditomidine-lidocaine-magnesium)

Active Comparator group

Description:

Intravenous infusion of Dexmeditomidine, lidocaine and magnesium sulfate

Treatment:

Drug: Intravenous infusion of dexmedetomidine, lidocaine, Magnesium sulfate