The Effect of Administration of Low Dose Adrenaline During Surgery on Bleeding During Hip Surgery

Rigshospitalet

Status and phase

Completed

Phase 3

Conditions

Intraoperative Blood Loss

Treatments

Drug: Adrenaline

Drug: Placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT01708642

RH-4074-OJ2

2012-002889-12 (EudraCT Number)

Details and patient eligibility

About

The purpose of this study is to evaluate the effect of intraoperative administration of low-dose adrenaline on intraoperative blood loss in patients undergoing hip surgery.

Full description

Hip arthroplasty is associated with bleeding, anemia and the need for allogeneic transfusion. Administration of low-dose adrenaline activates the coagulation system and may decrease intraoperative and immediate postoperative bleeding. Thus, the aim of this study is to evaluation whether intraoperative IV-administration of low-dose adrenaline reduces bleeding in elective total hip arthroplasty.

Enrollment

106 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age > 18 years.
Scheduled for primary unilateral hip arthroplasty
Able to give consent

Exclusion criteria

Allergy towards adrenaline
Current treatment with: ADP receptor inhibitors or Vitamin K antagonists (within 5 days), Factor Xa inhibitors or Thrombin inhibitors (within 1 day), heparin (excluding low molecular weight heparin for perioperative thromboprophylaxis).
Current treatment with tricyclic antidepressants
Use of MAO inhibitors (within previous 14 days) or COMT inhibitors (within 2 days).
Acute coronary syndrome / myocardial infarction within the previous 6 months.
not willing to accept blood transfusion
Participation in other clinical trial within previous 30 days
Women of childbearing age (without menopause for at least 12 months)
Glaucoma
Pheochromocytoma
Low serum K+ (< 3.0 mmol/L)
Thyrotoxicosis
Digoxin intoxication
Alcohol og drug abuse (investigators judgement)