The Effect of Aerobic Exercise on Learning After Stroke

Kansas Board of Regents

Status and phase

Completed

Phase 1

Conditions

Stroke

Treatments

Behavioral: Rehabilitation exercise

Study type

Interventional

Funder types

Other

Identifiers

NCT00228306

9903 (Other Identifier)

Am Heart Assn 0530208N

Details and patient eligibility

About

Determine if attaining aerobic fitness is beneficial in producing cortical neuroplasticity in individuals with chronic stroke.

Full description

Crossover clinical trial. Experimental group undergoes 3x/wk/6 months of aerobic conditioning. Control group performs usual daily activities. All participants will be assessed with cognitive and motor behavioral testing at baseline, 3, 6, 9 and 12 months.

Enrollment

38 patients

Sex

All

Ages

18 to 85 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Single ischemic stroke occuring 6-72 months prior
Fugl-Meyer score (upper + lower extremity) 45 or greater
Mini mental status score of >23
approval of the subject's medical doctor

Exclusion criteria

already performing >20 min of cardiovascular exercise 3x/wk or more
alcohol consumption of >2 oz. liquor, 8 oz. wine or 24 oz beer/day
cardiac history of unstable angina, recent myocardia infarction within the last 3 months, congestive heart failure, significant valve dysfunction
medical history of recent hospitalization (> 3 months) for medical illness
symptomatic peripheral arterial occlusive disease
orthopedic or chronic pain conditions restricting exercise
pulmonary or renal failure
active cancer
unstable hypertension (>160/100 mmHg)
diabetes mellitus (fasting glucose > 180 NG./dk, HgA1C > 10%) that is unable to be controlled < month
receptive or expressive aphasia as indicated on MMSE
multiple strokes or other neuromuscular conditions
major depression that is untreated using the Beck depression inventory