The Effect of Agomelatine or Fluoxentine on Heart Rate Variability in Patients With Major Depressive Disorder

National Taiwan University

Status

Withdrawn

Conditions

Depressive Disorder, Major

Treatments

Drug: Fluoxentine

Drug: Agomelatine

Study type

Interventional

Funder types

Other

Identifiers

NCT00451490

200610027R

Details and patient eligibility

About

Phase advance of HRV will be anticipated in agomelatine group. It is anticipated that both agomelatine and floxentine will increase HRV at the end of the treatment.

Full description

Phase advance of HRV will be anticipated in agomelatine group. It is anticipated that both agomelatine and floxentine will have equal efficacy in improvement of depressive symptoms and increasement of HRV at the end of the treatment.

Enrollment

24 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Asian patients
Male or female
18 to 65 years outpatients
DSM-IV-TR criteria for Major Depressive Disorder

Exclusion criteria

Patients with cardiac conditions and other physical conditions contraindicated for drug study
Shift worker
Patients known to be non-responders to fluoxetine treatment
Pregnancy, or breastfeeding