The Effect of Alfa-Adrenergic Receptor Blockade on Insulin-Stimulated Forearm Glucose Uptake and Metabolism in Chronic Heart Failure

Radboud University Medical Center

Status: Unknown

Conditions: Heart Failure, Congestive

Treatments: Drug: phentolamine

Study type: Interventional

Funder types: Other

Identifiers

NCT00132106

CHFALFA

Details and patient eligibility

About

The activity of the sympathetic nervous system seems to influence the uptake (and handling) of glucose by the skeletal muscle of the forearm. Conditions in which sympathetic activity is increased seem to inhibit/reduce forearm glucose uptake. Inversely a decrease in sympathetic activity seems to increase glucose uptake. This study analyzes the effect of alfa-adrenergic receptor blockade (counteracting sympathetic influence) on insulin-stimulated forearm glucose uptake in patients with increased sympathetic activity (patients with chronic heart failure).

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Heart failure of at least New York Heart Association (NYHA) class II
• Left ventricular ejection fraction (LVEF) <= 40%
• Age 18-75 years

Exclusion criteria

• Alfa-blockers, or beta-blockers with alfa-blocking activity (carvedilol)
• Tricyclic antidepressants
• Warfarin derivatives (acetylic salicylic acid and clopidogrel are allowed)
• Hospitalisation in 6 weeks prior to the study
• Any change in medication in 6 weeks prior to the study
• Unstable angina
• Orthopnoea
• Known chronic disease of the autonomic nervous system
• Diabetes mellitus
• Oedema of the lower extremities, complicating the insertion of a venous catheter in a vein on the foot