The Effect of an Acute Bout of Exercise on High-sugar Meal Induced Endothelial Dysfunction

Texas Christian University

Status: Completed

Conditions: Endothelial Dysfunction

Treatments: Other: Exercise Condition; Other: Control Condition

Study type: Interventional

Funder types: Other

Identifiers

NCT02919488

CT2016MS2

Details and patient eligibility

About

The purpose of this study is to determine if postprandial (after a meal) endothelial (inner lining of blood vessels) dysfunction induced by a high sugar meal improves with a bout of exercise

Full description

Endothelial dysfunction is due to an imbalance between vasodilating and vasoconstricting substances produced by the endothelium. An imbalance in these substances limits the ability of the blood vessel to relax in response to a shear stress stimulus. Endothelial dysfunction is a major risk factor for cardiovascular disease.

High-sugar intakes result in postprandial hyperglycemia and endothelial dysfunction. Exercise may attenuate the endothelial dysfunction induced by a high-sugar meal. There are only two studies that have examined the effect of exercise on endothelial dysfunction induced by high-sugar intake. Both studies found that a bout of aerobic exercise attenuated the impaired flow mediated dilation induced by high-sugar ingestion. Neither study measured important markers of endothelial dysfunction such as blood nitric oxide, endothelin I, and angiotensin II concentrations, however. In addition, whether the same results apply to older post-menopausal women is unknown. Understanding how acute exercise affects meal-induced endothelial dysfunction in older women is important given that age is related to endothelial dysfunction and cardiovascular disease.

Enrollment: 22 patients

Sex: Female

Ages: 45 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Post-menopausal women
• Must be 45-70 years

Exclusion criteria

• Use of medications or supplements to lose weight
• Following a weight loss diet
• Smoking
• Heavy alcohol consumption
• Diabetes
• Heart disease
• Stroke
• Liver disease
• Kidney disease
• Untreated thyroid disease
• Anemia
• Uncontrolled hypertension
• Pulmonary disease that prevents exercise
• Orthopedic problems that prevents exercise
• Arthritis problems that prevent exercise
• Musculoskeletal problems that prevent exercise.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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22 participants in 2 patient groups

Exercise Condition

Experimental group

Treatment:

Other: Exercise Condition

Control Condition

Active Comparator group

Treatment:

Other: Control Condition