The Effect of Anesthesia on Systemic Inflammatory Immune Index in Major Abdominal Cancer Surgeries

Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital

Status: Completed

Conditions: Cancer of Endometrium; Systemic Immune Activation; Cancer Gi

Treatments: Other: Systemic inflammatory immmune index

Study type: Observational

Funder types: Other

Identifiers

NCT04891146

AbdurrahmanYAOTRH

Details and patient eligibility

About

The effects of different anesthesia methods on the immune system are variable. In this study, we investigated the effect of inhalation anesthesia and total intravenous anesthesia on the SII value in major abdominal cancer surgeries.

Full description

The study was planned prospectively, observationally, on a total of 90 patients who underwent major abdominal cancer surgery. 84 patients were evaluated. The patients were seperated in two groups as inhalation anesthesia and total intravenous anesthesia (TIVA). The demographic data of the patients, type of cancer, type of surgery performed, ASA classification, preoperative chemotherapy intake, preoperative hemogram, postoperative 2nd and 24th hour hemogram, intraoperative and postoperative blood transfusion, and duration of surgery were recorded. Platelet, neutrophil, lymphocyte and SII values were saved.

Enrollment: 84 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• major abdominal cancer surgeries

Exclusion criteria

• blood transfusion in last 72 hours
• patients with infection
• hematologic malignancy
• patient controlled analgesia

Trial design

84 participants in 2 patient groups

Inhalation anesthesia

Description:

Sevoflurane for opioid remifentanyl used

Treatment:

Other: Systemic inflammatory immmune index

Total Intravenous Anesthesia

Description:

Propofol for opioid remifentanyl used

Treatment:

Other: Systemic inflammatory immmune index