The Effect of Anesthetics Agents on Vascular Injury and Level of Syndecan-1 During Knee Surgery

Konkuk University Medical Center

Status: Completed

Conditions: Ischemia

Treatments: Drug: Desflurane group; Drug: propofol group

Study type: Interventional

Funder types: Other

Identifiers

NCT02756715

KUH1160100

Details and patient eligibility

About

Ischeic reperfusion injury lead to a cellular dyfunction and increase in soluble glycocalyx of blood flow. syndecan-1 was a marker of glycocalyx.

The purpose of this study is to prove the variation of level of serum syndecan-1 between preoperative and postoperative period.

Full description

The patients were allocated randomly to receive propofol or desflurane. Also, a total of 6ml of blood sample was obtained for total 6 times in consecutive order.

1. Preoperation (immediate before anesthesia induction)
2. Immediate before tourniquet off
3. 5 min after tourniquet off
4. PACU
5. postoperative 6 hours
6. postoperative 24 hours

Serum in blood will be obtained and level of serum cytokine will be evaluated by enzyme-linked immunosorbent assay

Enrollment: 80 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients who was planned to undergo knee surgery.

Exclusion criteria

• age < 20 years old
• history of previous cancer
• history of previous peripheral vascular disease
• Emergency surgery

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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80 participants in 2 patient groups

propofol group

Active Comparator group

Description:

The patient who anesthetized by using propofol.

Treatment:

Drug: propofol group

Desflurane group

Active Comparator group

Description:

The patient who anesthetized by using sevoflurane.

Treatment:

Drug: Desflurane group