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The Effect of Anesthetics Agents on Vascular Injury and Level of Syndecan-1 During Knee Surgery

K

Konkuk University Medical Center

Status

Completed

Conditions

Ischemia

Treatments

Drug: Desflurane group
Drug: propofol group

Study type

Interventional

Funder types

Other

Identifiers

NCT02756715
KUH1160100

Details and patient eligibility

About

Ischeic reperfusion injury lead to a cellular dyfunction and increase in soluble glycocalyx of blood flow. syndecan-1 was a marker of glycocalyx.

The purpose of this study is to prove the variation of level of serum syndecan-1 between preoperative and postoperative period.

Full description

The patients were allocated randomly to receive propofol or desflurane. Also, a total of 6ml of blood sample was obtained for total 6 times in consecutive order.

  1. Preoperation (immediate before anesthesia induction)
  2. Immediate before tourniquet off
  3. 5 min after tourniquet off
  4. PACU
  5. postoperative 6 hours
  6. postoperative 24 hours

Serum in blood will be obtained and level of serum cytokine will be evaluated by enzyme-linked immunosorbent assay

Enrollment

80 patients

Sex

All

Ages

20+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • patients who was planned to undergo knee surgery.

Exclusion criteria

  • age < 20 years old
  • history of previous cancer
  • history of previous peripheral vascular disease
  • Emergency surgery

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

80 participants in 2 patient groups

propofol group
Active Comparator group
Description:
The patient who anesthetized by using propofol.
Treatment:
Drug: propofol group
Desflurane group
Active Comparator group
Description:
The patient who anesthetized by using sevoflurane.
Treatment:
Drug: Desflurane group

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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