The Effect of Anesthetics on Oxidative Stress and Apoptosis Status in Children

Sun Yat-sen University

Status: Completed

Conditions: Anesthesia, General

Treatments: Drug: Sevoflurane; Drug: Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT02711280

[2014]114

Details and patient eligibility

About

The purpose of this study is to determine whether Propofol and Sevoflurane affect the oxidative stress and apoptosis status in children undergoing hypospadias repair surgery.

Enrollment: 47 patients

Sex: Male

Ages: 1 to 3 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiology (ASA) I-II, undergoing selective surgery for hypospadias repair.

Exclusion criteria

• a history of developmental delay or mental retardation, which could make observational pain intensity assessment outside the norm;
• a history of central nervous system diseases;
• a known or suspected coagulopathy;
• a known allergy to any of the study drugs;
• abnormalities of the sacrum and any signs of infection at the site of the proposed caudal block.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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47 participants in 2 patient groups

Sevoflurane General anesthesia

Experimental group

Description:

Anesthesia was induced with 8% sevoflurane with 8L/min oxygen. Anesthesia was maintained with 1-3% sevoflurane in oxygen/air mixture.

Treatment:

Drug: Sevoflurane

Propofol General anesthesia

Experimental group

Description:

Anesthesia was induced with propofol 4mg/kg. Anesthesia was maintained with propofol 7-12mg/kg/h.

Treatment:

Drug: Propofol