The Effect Of Antenatal Corticosteroids On Early And Late Perinatal Outcomes

Sanliurfa Mehmet Akif Inan Education and Research Hospital

Status: Completed

Conditions: Perinatal Problems; Antenatal Corticosteroid; Preterm Pregnancy

Treatments: Other: participants receiving Corticosteroid

Study type: Interventional

Funder types: Other

Identifiers

NCT06164080

2011-KAEK-25 2021/05-10

Details and patient eligibility

About

In this study, the investigators aims to evaluate whether antenatal corticosteroid administration to women likely to give birth in the late preterm period will reduce early and late neonatal complications and contribute to the literature in this sense.

Full description

This study is a single-center prospective case-control study investigating the effect of antenatal corticosteroids administered in the late preterm period on early and late perinatal outcomes. 459 patients who gave birth between 34-37 weeks between June 1,2021 to October 1,2022 in the Obstetrics and Gynecology Clinic of the University of Health Sciences were included. Patient were divided into two groups antenatal corticosteroid administration (n:231) and non-administration (n:228). Postpartum early and late perinatal outcomes were compared between these two groups.

Enrollment: 459 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All pregnant women who had normal vaginal delivery, cesarean section or operative delivery between 34-37 weeks
• Singleton pregnancies resulting in a live birth

Exclusion criteria

• Twin pregnancies
• All births before 34 weeks or after 37 weeks
• Pregnant women with intrauterine ex fetus
• Fetuses with major congenital and chromosomal abnormalities
• Pregnant women who administrated antenatal corticosteroids for any reason before 34 weeks

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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459 participants in 2 patient groups

Antenatal corticosteroid non-administration

No Intervention group

Description:

Pregnant women who did not use antenatal corticosteroid before 34 weeks

Antenatal corticosteroid administration

Active Comparator group

Description:

Pregnant women using antenatal corticosteroids for any reason before 34 weeks

Treatment:

Other: participants receiving Corticosteroid