The Effect of Antiemetics on Bowel Preparation Before Colonoscopy

Shanghai Jiao Tong University

Status and phase: Unknown; Phase 4

Conditions: Bowel Preparation

Treatments: Drug: sulpiride; Drug: Domperidone

Study type: Interventional

Funder types: Other

Identifiers

NCT04583111

RJYYXHNK-006

Details and patient eligibility

About

Polyethylene glycol (PEG) is one of the most common laxatives used in colonoscopy. However, 5 - 15% of patients can not complete the preparation due to its poor taste and large volume. So this study is aimed to explore the effect of antiemetics on abdominal discomforts associated with PEG.

Enrollment: 200 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18-70 years patients scheduled for colonoscopy

Exclusion criteria

• intestinal obstruction or hemorrhage;
• allergy to domperidone, sulpiride or PEG;
• pregnancy or breastfeeding;
• previous use of prokinetics within 1 month.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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200 participants in 3 patient groups

Domperidone group

Experimental group

Description:

Patients in Domperidone group took 10mg of domperidone 30min before PEG.

Treatment:

Drug: Domperidone

Sulpiride group

Experimental group

Description:

Patients in Sulpiride group took 100mg of sulpiride 30min before PEG.

Treatment:

Drug: sulpiride

Control group

No Intervention group

Description:

Patients in Control group followed the regular routine of 3L split-dose of PEG.