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The Effect of Antihypertensive Agents Concerning With Hemodynamics and Reduction of Anaesthetics in Orthognathic Surgery

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Yonsei University

Status

Completed

Conditions

Orthognathic Surgery

Treatments

Drug: ACE inhibitor(Enapril)
Drug: b-blocker(Atenolol)
Other: control

Study type

Interventional

Funder types

Other

Identifiers

NCT01839253
4-2012-0422

Details and patient eligibility

About

For those who receive hypotensive anesthesia in orthognathic surgeries, the investigators premedicate with anti-hypertensive agent so that it decreases the occurence of tachycardia and the rebound hypertension due to hypotensive anesthesia, enabling us to compare hemodynamic stability and reduction of anesthetic agents during the operation.

Enrollment

75 patients

Sex

All

Ages

18 to 29 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  1. ASA class I-II
  2. obtaining written informed consent from the parents
  3. aged 18-29 years who were undergoing orthognathic surgery.

Exclusion criteria

  1. Hypertension patients with anti-hypertensive agents
  2. chronic renal failure or End stage renal disease patients.
  3. renal artery stenosis history.
  4. Patients who are with medication due to systemic disease.
  5. symptomatic asthma
  6. Drug hyperactivity
  7. neurological or psychiatric illnesses
  8. mental retardation
  9. patients who can't read the consent form due to illiterate or foreigner

Trial design

Primary purpose

Supportive Care

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

75 participants in 3 patient groups, including a placebo group

Atenolol
Experimental group
Description:
In each group, premedication with either b-blocker (Atenolol) or ACE inhibitor (enalapril) or nothing (control group) in the preparation room.
Treatment:
Drug: b-blocker(Atenolol)
Enalapril
Active Comparator group
Description:
In each group, premedication with either b-blocker (Atenolol) or ACE inhibitor (enalapril) or nothing (control group) in the preparation room.
Treatment:
Drug: ACE inhibitor(Enapril)
control
Placebo Comparator group
Description:
none of antihypertensive agents
Treatment:
Other: control

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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