The Effect of Antihypertensive Agents Concerning With Hemodynamics and Reduction of Anaesthetics in Orthognathic Surgery

Yonsei University

Status: Completed

Conditions: Orthognathic Surgery

Treatments: Drug: ACE inhibitor(Enapril); Drug: b-blocker(Atenolol); Other: control

Study type: Interventional

Funder types: Other

Identifiers

NCT01839253

4-2012-0422

Details and patient eligibility

About

For those who receive hypotensive anesthesia in orthognathic surgeries, the investigators premedicate with anti-hypertensive agent so that it decreases the occurence of tachycardia and the rebound hypertension due to hypotensive anesthesia, enabling us to compare hemodynamic stability and reduction of anesthetic agents during the operation.

Enrollment: 75 patients

Sex: All

Ages: 18 to 29 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. ASA class I-II
2. obtaining written informed consent from the parents
3. aged 18-29 years who were undergoing orthognathic surgery.

Exclusion criteria

1. Hypertension patients with anti-hypertensive agents
2. chronic renal failure or End stage renal disease patients.
3. renal artery stenosis history.
4. Patients who are with medication due to systemic disease.
5. symptomatic asthma
6. Drug hyperactivity
7. neurological or psychiatric illnesses
8. mental retardation
9. patients who can't read the consent form due to illiterate or foreigner

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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75 participants in 3 patient groups, including a placebo group

Atenolol

Experimental group

Description:

In each group, premedication with either b-blocker (Atenolol) or ACE inhibitor (enalapril) or nothing (control group) in the preparation room.

Treatment:

Drug: b-blocker(Atenolol)

Enalapril

Active Comparator group

Description:

In each group, premedication with either b-blocker (Atenolol) or ACE inhibitor (enalapril) or nothing (control group) in the preparation room.

Treatment:

Drug: ACE inhibitor(Enapril)

control

Placebo Comparator group

Description:

none of antihypertensive agents

Treatment:

Other: control