The Effect of Apple Cider Vinegar Supplementation on 24-hour Urine Chemistry in Adults

The University of Chicago

Status: Begins enrollment this month

Conditions: Urine Specimen Collection; Kidney Stones

Treatments: Dietary Supplement: Apple Cider Vinegar

Study type: Interventional

Funder types: Other

Identifiers

NCT07389226

IRB25-0715

Details and patient eligibility

About

This is a single-center prospective cohort study to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.

Full description

The primary objective of this study is to determine whether a two-week course of daily ACV supplementation significantly changes an individual's urine chemistry. The investigators will study this in healthy individuals and individuals with kidney stones.

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Controls: Adults above the age of 18.
• Kidney stone patients: Adults above the age of 18.
• History of majority (>50%) calcium oxalate kidney stones

Exclusion criteria

• Anyone with a history of calcium phosphate stones (>50% calcium phosphate), uric acid stones, struvite stones, recent urinary tract instrumentation (<30 days), or recurrent urinary tract infections.
• Any individual who has had ACV outside of normal consumption in the prior month will be excluded.
• Any individual who has a history of a negative reaction (increased acid reflux, allergy) to ACV will also be excluded.
• Any individual with chronic kidney disease, underlying acid base disorder will also be excluded.

Trial design

Primary purpose: Supportive Care

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 1 patient group

kidney stone patients and healthy participants

Experimental group

Description:

Each participant will be asked to complete a basic metabolic panel prior to initiating the study to ensure that no baseline metabolic derangements exist. On day 1, participants will complete a 24-hour urine collection and 48-hour food diary at home. Participants will then consume an ACV gummy containing 60 meq daily for 14 consecutive days.

Treatment:

Dietary Supplement: Apple Cider Vinegar