The Effect of Apple Fruit Extract (Malus Sylvestris Mill) as an Antioxidant and Anti-Inflammatory on Allergic Rhinitis

Universitas Sebelas Maret

Status: Completed

Conditions: Rhinitis, Allergic, Perennial

Treatments: Other: Apple Extract; Other: Loratadine 10 Mg; Other: Quercetin; Other: Fluticasone Furoate

Study type: Interventional

Funder types: Other

Identifiers

NCT07380178

007/12/2024

Details and patient eligibility

About

This study was conducted to see before and after treatment whether it provided improvement in the patient's clinical symptoms.

Full description

This research is the first to be conducted with preliminary research on humans.

Enrollment: 40 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged 18 - 60 years who have signed an informed consent
• Diagnosed with persistent allergic rhinitis with a Skin Prick Test or Positive IgE Examination.

Exclusion criteria

• The presence of complications in the nose such as nasal septum deviation, polyps, rhinosinusitis
• Have undergone specific immunotherapy for 2 years
• Use of drugs that affect allergy test results: antihistamines, corticosteroids, antihypertensive drugs, and decongestants
• Pregnancy and Breastfeeding

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

---

40 participants in 4 patient groups

Control Group

Experimental group

Description:

Loratadine 10 mg/day and Fluticasone Furoate 27.5 mcg twice daily.

Treatment:

Other: Fluticasone Furoate

Other: Loratadine 10 Mg

Treatment A: Quercetin 100 mg

Experimental group

Description:

Loratadine 10 mg/day, Fluticasone Furoate 27.5 mcg twice daily, and Quercetin 100 mg/day.

Treatment:

Other: Fluticasone Furoate

Other: Loratadine 10 Mg

Other: Quercetin

High-Dose Quercetin

Experimental group

Description:

Loratadine 10 mg/day, Fluticasone Furoate 27.5 mcg twice daily, and Quercetin 200 mg/day.

Treatment:

Other: Fluticasone Furoate

Other: Loratadine 10 Mg

Other: Quercetin

Apple Extract Only

Experimental group

Description:

Apple fruit extract (Malus sylvestris Mill) and Quercetin 200 mg/day.

Treatment:

Other: Quercetin

Other: Apple Extract