The Effect of Arterial Oxygen Parameters on Antioxidant Parameters

Bursa Yüksek İhtisas Education and Research Hospital

Status: Completed

Conditions: Cardiovascular Diseases

Treatments: Diagnostic Test: taken venous sample

Study type: Observational

Funder types: Other

Identifiers

NCT04627220

Bursa High Education Hospital

Details and patient eligibility

About

We aimed to measure the changes in your blood values caused by different but safe oxygen values used by us during your heart surgery under laboratory conditions.

Full description

Hyperoxia is often preferred due to the risk of tissue hypoxia that may develop in cardiac surgery. It is thought that with hyperoxemia, ischemia reperfusion damage increases, microcirculation is impaired and tissue oxygenation is impaired.Oxidative damage occurs in cases of increased oxidative stress and impaired antioxidant balance.It was aimed to investigate oxidative damage by recording modified albumin and thiol disulfide in blood simultaneously by recording arterial oxygen levels at determined times during cardiac surgery.

Enrollment: 100 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patient scheduled for cardiac surgery
• ASA>3
• Aged 18-75 years

Exclusion criteria

• those with valvular disease
• EF<%40
• BMI>40 kg/m2
• presence of arrhythmia that impairs hemodynamics
• previous history of cerebrovascular
• diagnosed with end-stage organ failure

Trial design

100 participants in 2 patient groups

group 1

Description:

Group 1: Pressure of arterial oxygen\> 200 mmHg during the coronary surgery

Treatment:

Diagnostic Test: taken venous sample

group 2

Description:

Group 2: Pressure of arterial oxygen\<200 mmHg and \>80 mmHg during the coronary surgery

Treatment:

Diagnostic Test: taken venous sample