The Effect of Artificial Sweeteners on Blood Glucose Response

Northumbria University

Status: Withdrawn

Conditions: Taste Receptors; Blood Glucose; Intestinal Absorption; Nutrient Sensing; Appetite

Treatments: Dietary Supplement: Artificial Sweeteners

Study type: Interventional

Funder types: Other

Identifiers

NCT01246492

34AK1

Details and patient eligibility

About

The purpose of this study is to determine whether the presece of the artificial sweeteners aspartame, saccharin and asceulfame-k affect the blood glucose responses to an orally incested glucose solution.

Full description

Sweet taste receptors, similar to those located on the lingual taste buds have been located along in the lining of the gut. Recent studies have demonstrated that activation of these sweetness taste receptors, either by sugars such as glucose, fructose, lactose, or artificial sweeteners such as saccharin and aspartame can influence the way nutrients, including glucose are absorbed from the gut into the bloodstream. Studies in animal models have shown that activation of the sweet taste receptors can increase the expression of the sodium-dependant glucose transporter 1 (SGLT1) and glucose transporter 2 (GLUT2) which transport glucose from the lumen into the bloodstream. Thus providing a potential mechanism by which glucose uptake can be regulated. Although artificial sweeteners stimulate the sweet taste receptors, they have little nutritive value, so that when they are consumed in the absence of any other nutrients there is little effect on blood glucose response. However, the effects of consuming artificial sweeteners in combination with sugars such as glucose is unclear. The purpose of this study is to investigate whether the addition of artificial sweeteners to an orally consumed glucose solution affects the rate at which the glucose appears in the blood.

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy subjects
• Aged 18-45 years
• BMI (19-25 kg/m2)
• Weight stable in past 3 months

Exclusion criteria

• Smoking
• Females who are pregnant of breastfeeding
• Regular intake of emdication, other than females taking oral contraceptives
• Medical illness
• Gastrointestinal disorders
• Food allergies

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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0 participants in 4 patient groups, including a placebo group

45g glucose

Placebo Comparator group

Description:

glucose water

Treatment:

Dietary Supplement: Artificial Sweeteners

45g glucose + 150mg aspartame

Active Comparator group

Description:

glucose water aspartame

Treatment:

Dietary Supplement: Artificial Sweeteners

45g glucose + 20 mg saccharin

Active Comparator group

Description:

glucose water saccharin

Treatment:

Dietary Supplement: Artificial Sweeteners

45g glucose + 85mg asculfame - K

Active Comparator group

Description:

glucose water aseulfame- k

Treatment:

Dietary Supplement: Artificial Sweeteners