The Effect of Aspirin on Recurrent Acute Pancreatitis

Air Force Military Medical University of People's Liberation Army

Status

Enrolling

Conditions

Prevention

Recurrent Acute Pancreatitis

Aspirin

Treatments

Drug: 100mg aspirin

Study type

Interventional

Funder types

Other

Identifiers

NCT06185621

KY20232303-F-1

Details and patient eligibility

About

Recurrent acute pancreatitis (RAP) was defined as two or more occurrences of acute pancreatitis, which was associated with higher percentages of morbidities and mortalities, lower patients' life quality and increased health-care costs. Current interventions, including cholecystectomy and abstain from drinking were reported to be effective methods for preventing the recurrences of biliary and alcoholic etiologies, respectively. However, there were no effective preventions for other etiologies, such as idiopathic etiologies. Non-steroid anti-inflammatory drugs (NSAIDs), including indomethacin, diclofenac and aspirin could inhibiting the inflammatory cascade of pancreatitis. In this study, we aimed at exploring the effects of 100mg aspirin on reducing the occurrences of recurrent acute pancreatitis.

Enrollment

23 estimated patients

Sex

All

Ages

14 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients with with recurrent acute pancreatitis

Exclusion criteria

Less than 2 episodes of acute pancreatitis in the past year
Latrogenic AP (pancreatitis due to endoscopic retrograde cholangiopancreatography, surgery, or after other invasive treatment). Iatrogenic pancreatitis will not count as an episode of recurrent pancreatitis
Previous allergy to Non-Steroid Anti-inflammatory Drugs (NSAIDs)
Regularly taking aspirin or other NSAIDs >3 doses per week
Contradictions for the medications of NSAIDs, including Active peptic ulcer disease or gastrointestinal hemorrhage within 3 months or previous peptic ulcer, history of significant hepatic or renal disease, platelet count less than 100X10^9/L or international normalized ratio (INR) >1.5)
Biliary stones
Receiving endoscopic sphincterotomy and/or pancreatic stent placement and/or cholecystectomy and/or pancreatic surgery after the latest pancreatitis or planning to undergo one of those interventions within preceding 2 years
Patients with the level of serum triglycerides of >5.65 mmol/L and did not receive regular lipid-lowering therapy
Primary hyperparathyroidism has been well-treated after last episode of pancreatitis and recruitment or will be operated in <2 years
Patients with previously heavy alcohol consumption (50g/day for men, 40g/day for women) and have not quit drinking, or have significant withdrawal symptoms
Pregnant or breastfeeding patients
Inability to give informed consents