The Effect Of Aspirin On Survival in in Patients Undergoing Chronic Hemodialysis

Shanghai Jiao Tong University School of Medicine

Status: Completed

Conditions: Hemodialysis

Treatments: Drug: acetylsalicylic acid

Study type: Interventional

Funder types: Other

Identifiers

NCT02261025

20120308

Details and patient eligibility

About

The aim of present study is to examine the effect of low-dose aspirin on the incidence of cardiovascular events and mortality in patients undergoing chronic hemodialysis.

Full description

This study prospectively evaluate the impacts of low dose aspirin on survival and cardio-cerebral vascular events in a large cohort of Chinese patients undergoing chronic hemodialysis. Between January 2008, consecutive patients with hemodialysis with aspirin were enrolled.We examine the association of aspirin with all-cause mortality in patients matched by propensity scores using the Kaplan-Meier method and Cox models in "intention-to-treat" analyses.The secondary endpoint was rate of cardio-cerebral events.

Enrollment: 410 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

All patients aged 18 to 85, undergoing chronic hemodialysis, who have none of the following exclusion criteria.

Exclusion criteria

History of gastric or duodenal ulcers Known allergy to aspirin or other NSAIDs

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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410 participants in 2 patient groups

Aspirin group

Experimental group

Description:

Aspirin 75-100mg,per day，oral

Treatment:

Drug: acetylsalicylic acid

non-aspirin group

No Intervention group

Description:

No interventions