The Effect of β-hydroxy-β-methylbutyrate Supplementation on Physical Capacity and Body Composition in Trained Athletes

Poznan University of Medical Sciences (PUMS)

Status and phase: Completed; Phase 3

Conditions: Supplementation; Supplements; Sport

Treatments: Dietary Supplement: β-hydroxy-β-methylbutyrate and a placebo supplementation

Study type: Interventional

Funder types: Other

Identifiers

NCT03028649

NN312262340

Details and patient eligibility

About

The purpose of this study was to verify the effect of 12-week with β-hydroxy-β-methylbutyrate (HMB) and a placebo (PLA) supplementation on body composition, anaerobic and aerobic capacity, as well as concentrations of the selected biochemical blood markers in trained athletes, in a randomised, double-blind, placebo-controlled crossover trial.

Full description

The effect of HMB supplementation is of great interest in sport. In view of the inconclusive character of the results of the studies conducted to date and of a relatively low number of studies investigating the effectiveness of HMB supplementation over a longer period on a large population of trained athletes, the aim of this study was to verify the effect of 12-week with HMB and a placebo supplementation on body composition, anaerobic and aerobic capacity, as well as concentrations of the selected biochemical blood markers in trained athletes, in a randomised, double-blind, placebo-controlled crossover trial.

Enrollment: 58 patients

Sex: Male

Ages: 17 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• written consent to participate,
• male
• a current medical clearance to practice sports,
• training experience: at least 5 years,
• minimum of 6 workout sessions a week (minimum 3 in the practiced sports discipline).

Exclusion criteria

• current injury,
• any health-related contraindication,
• declared general feeling of being unwell,
• unwilling to follow the study protocol.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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58 participants in 2 patient groups, including a placebo group

β-hydroxy-β-methylbutyrate (HMB)

Experimental group

Description:

Group taking oral supplementation with calcium salt of β-hydroxy-β-methylbutyric acid produced by Olimp Laboratories. A single capsule contained 1250 mg Ca-HMB, which corresponds to 1000 mg of β-hydroxy-β-methylbutyrate. Interventions: The experimental procedure for each athlete included a 12-week HMB supplementation - 3 capsules of the assigned preparation a day in 3 doses: upon waking, immediately after training, and before sleep. On non-training days, the participants were instructed to consume one serving with each of three separate meals throughout the day. Between the 12-week HMB and PLA or a PLA and HMB treatment, a 10-day washout period was introduced.

Treatment:

Dietary Supplement: β-hydroxy-β-methylbutyrate and a placebo supplementation

Placebo (maltodextrin)

Placebo Comparator group

Description:

Group taking oral supplementation with placebo (maltodextrin). A single capsule contained 1000 mg of maltodextrin. Interventions: The experimental procedure for each athlete included a 12-week placebo administration - 3 capsules of the assigned preparation a day in 3 doses: upon waking, immediately after training, and before sleep. On non-training days, the participants were instructed to consume one serving with each of three separate meals throughout the day. Between the 12-week HMB and PLA or a PLA and HMB treatment, a 10-day washout period was introduced.

Treatment:

Dietary Supplement: β-hydroxy-β-methylbutyrate and a placebo supplementation