The Effect of Bathing and Moisturizers on Skin Hydration in Atopic Dermatitis: an in Vivo Study

Srinakharinwirot University

Status: Completed

Conditions: Dermatitis, Atopic

Treatments: Procedure: bathing and moisturizer application

Study type: Interventional

Funder types: Other

Identifiers

NCT02028546

Srinakharinwirot fund

Details and patient eligibility

About

The purpose of this study is to determine the hydration effect of various regimens of skin bathing and moisturizer application on atopic dermatitis

Enrollment: 22 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• male or female;
• Age range 18-45 years;
• Subjects have history and physical findings consistent with mild to moderate AD with SCORAD score ≤ 40;
• Stop using some drugs such as oral corticosteroid for at least 4 weeks, topical corticosteroid and calcineurin inhibitor for at least 2 weeks, food supplement such as evening primrose oil, wheat extract Flax seed oil sunflowerseed oil, borage oil and fish oil for at least 3 months;
• Subjects who have signed the written informed consent.

Exclusion criteria

• Subjects who have medical histories such as zinc or essential fatty acid deficiency, end stage renal disease, hypothyroidism, human immunodeficiency virus (HIV), malignancies, obstructive biliary disease, diabetes mellitus and in those who have had radiation or other medical histories that may interfere the outcome;
• Subjects who ingest drugs that could interfere with the study results such as diuretics, antiandrogens, lipid reducing agents, isotretinoin cimetidine;
• Subjects cannot enroll until the end of the project;
• Subjects who have allergy to any ingredient in the moisturizer or cleanser that will be used in the protocol;
• Pregnant woman or lactating woman.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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22 participants in 2 patient groups

Water

Experimental group

Description:

The patients in water group were soaking an arm for 10 minutes with tap water before application of moisturizer. (Excepted the 4th regimen included no bathing, waited for 10 minutes and followed by moisturizer application.)

Treatment:

Procedure: bathing and moisturizer application

mild cleanser

Experimental group

Description:

The patients in mild cleanser group were soaking an arm for 10 minutes with mild cleanser before application of moisturizer. (Excepted the 4th regimen included no bathing, waited for 10 minutes and followed by moisturizer application.) Non soap base cleanser contained Sodium Cocoyl Isethionate was used in this mild cleanser arm.

Treatment:

Procedure: bathing and moisturizer application