The Effect of Berries on Lung Cancer Tumors

University of Louisville (UOFL)

Status: Terminated

Conditions: Non Small Cell Lung Cancer

Treatments: Dietary Supplement: berry powder

Study type: Interventional

Funder types: Other

Identifiers

NCT00681512

BCC-LUN-07-002 (Other Identifier)

08.0040

Details and patient eligibility

About

The purpose of this study is to determine how berries affect cancer tumors in patients with non-small cell lung cancer.

Full description

In the United States, more people (161,840 per year) die of lung cancers than of prostate cancer, breast cancer and colon cancer combined. Presently, there are over 43 million current smokers and over 47 million ex-smokers living in the US. Due to the lag time between smoking and the development of cancer, there are significant numbers of ex-smokers and current smokers who may develop lung cancer compared to never smokers.

Recent studies in animals have shown that berries, given as a dietary supplement, are highly effective against certain types of cancers. In a study involving mice with lung tumors, mice that had consumed a mixture of berries developed fewer tumors and had less tumor growth than mice that did not consume berries.

The berries used in this study will consist of blueberries, black raspberries, or a mixture of both.

Enrollment: 6 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria (lung cancer survivors):

• men treated for lung cancer, women treated for lung cancer and with no child-bearing potential (hysterectomy, tubal ligation, post-menopausal women)

Exclusion Criteria (lung cancer survivors):

• women who are on hormone replacement therapy
• women who are pregnant, or planning for pregnancy
• history of lung transplant
• prison inmate
• inability to take oral medication or food
• known or suspected allergy to berries or berry products
• HIV patients

Inclusion Criteria (volunteers):

• adult men, adult women with no child bearing potential (hysterectomy, tubal ligation, post-menopausal women)

Exclusion Criteria (volunteers):

• women who are on hormone replacement therapy
• women who are pregnant, or planning for pregnancy
• history of lung transplant
• prison inmate
• inability to take oral medication or food
• known or suspected allergy to berries or berry products
• HIV patients

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)