The Effect of Caffeine on Ischemic Preconditioning

Radboud University Medical Center

Status: Completed

Conditions: Caffeine; Ischemia-Reperfusion Injury; Ischemic Preconditioning

Treatments: Drug: Technetium-TC99m-labeled Annexin A5; Procedure: ten minutes forearm ischemia; Procedure: ischemic forearm exercise; Drug: caffeine

Study type: Interventional

Funder types: Other

Identifiers

NCT00184912

CAFIRI

Details and patient eligibility

About

Ischaemic preconditioning (IP) describes the phenomenon that brief periods of ischaemia render the (myocardial) muscle more resistant to a subsequent more prolonged period of ischaemia and reperfusion. Animal studies have provided evidence that adenosine receptor stimulation is an important mediator of IP. As caffeine is an effective adenosine receptor antagonist already at concentrations reached after regular coffee consumption, we aimed to assess whether caffeine impairs IP in humans in vivo. We used a novel and well-validated model to study IP in humans: 99m-Tc-annexin A5 scintigraphy in forearm skeletal muscle.

24 healthy volunteers were randomly assigned to either caffeine (4 mg/kg/iv in 10 minutes) or saline before a protocol for IP.

Sex: Male

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy male volunteers

Exclusion criteria