The Effect of Calcium on Fecal Fat and Energy Excretion

University of Copenhagen

Status: Unknown

Conditions: Obesity

Treatments: Other: Dairy calcium

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00519909

H-KF-01-144/02

Details and patient eligibility

About

The overall purpose of this study is to examine the effect of calcium on fecal fat and energy excretion.

Full description

Several reports have found inverse associations between calcium intake and body weight. Few intervention studies have shown that a high calcium diet resulted in a greater body weight loss than a low calcium diet. The mechanism is not clear, but one possible explanation is reduced absorption of fat in the gut, due to formation of insoluble calcium fatty acid soaps or binding of bile acids which impairs the formation of micelles.

The aim of this study is to examined if a high calcium intake from dairy products, in diets high or normal in fat content, have an effect on fecal energy and fat excretion, concentrations of substrates involved in energy metabolism and blood pressure.

Enrollment: 15 estimated patients

Sex: Male

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy meals
• BMI 24-31 kg/m2
• age between 18-50 years

Exclusion criteria

• donation of blood 6 months before and under the study
• milk allergy, diabetes, hypertension, hyperlipidemia, cronic infectious disease
• use of dietary supplements 3 months before and under the study
• smoking
• elite athletes
• use of medication

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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15 participants in 5 patient groups

1

Other group

Description:

Diet with high content of calcium and high content of fat

Treatment:

Other: Dairy calcium

2

Other group

Description:

Diet with low content of calcium and high content of fat

Treatment:

Other: Dairy calcium

3

Other group

Description:

Diet with high content of calcium and normal content of fat

Treatment:

Other: Dairy calcium

4

Other group

Description:

Diet with low content of calcium and normal content of fat

Treatment:

Other: Dairy calcium

5

Other group

Description:

Diet with high content of calcium fra supplement and high content of fat

Treatment:

Other: Dairy calcium