The Effect of Calcium Supplementation on Insulin Resistance and 24h Blood Pressure

Aristotle University Of Thessaloniki

Status and phase

Completed

Phase 4

Conditions

Hypertension

Diabetes

Insulin Resistance

Treatments

Dietary Supplement: tablets each containing of 1000mg elemental calcium (Mega-Calcium Sandoz)

Study type

Interventional

Funder types

Other

Identifiers

NCT00549536

A3242

Details and patient eligibility

About

Increased levels of intracellular calcium are thought to diminish maximal cellular response to insulin and induce insulin resistance. Also, both hypertension and diabetes are thought to be conditions of altered intracellular ionic state. The aim of the present study is to investigate the possible effect of oral calcium supplementation on intracellular ions, insulin sensitivity, 24-h blood pressure and sodium/hydrogen exchanger activity in patients with type 2 diabetes and essential hypertension.

Enrollment

31 patients

Sex

All

Ages

18 to 85 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients with hypertension, diabetes and the metabolic syndrome (according to the definition of the National Cholesterol Education Program, Adult Panel III (NCEP, ATP III).
Signed the concent form

Exclusion criteria

Secondary Hypertension
Stage II or III hypertension
History of renal disease
Sleep apnea
Acute or chronic inflammation
History of coronary artery disease
Heart failure stage III or IV according to the New York Heart Association
Active liver disease
History of malignancy
Parathyroidism
History of kidney stones
Calcium supplement ingestion
Drugs that alter insulin resistance
Treatment with insulin
Alcohol abuse or other conditions with poor prognosis
Treatment with non-inflammatory steroid agents, corticosteroids, or any other treatment that affects blood pressure