The Effect of Cannabidiol in Learning and Memory of Adults

Colorado State University (CSU)

Status and phase: Completed; Phase 2

Conditions: Memory

Treatments: Drug: Cannabidiol (246mg press pill); Drug: Placebo (246mg press pill)

Study type: Interventional

Funder types: Other

Identifiers

NCT06074172

MD012420BM

Details and patient eligibility

About

The main objectives of this study were to test if a singular dose of Cannabidiol (1) enhances the learning and memory of healthy human subjects, (2) test if Cannabidiol has negative effects on Retroactive and Proactive Interference during learning, (3) and test if demographic factors will influence CBD's modulation of human learning and memory.

Full description

Using a randomized, double-blind, placebo-controlled two-arm case-crossover trial, this study investigates the effect of 246 milligrams (mg) of Cannabidiol (CBD) on the learning and memory scores of human subjects, as well as the effect of Cannabidiol on Proactive and Retroactive Interference. This study also investigated the influence of demographic factors on CBD's modulation of human learning and memory.

This study was conducted at Colorado State University-Pueblo (CSU Pueblo) with volunteers recruited from CSU Pueblo and the local Pueblo community. Fifty-seven subjects were randomized in a double-blind manner to receive either CBD or placebo before completing two versions of learning and memory assessments. Each version of the learning and memory assessment included the Montreal Cognitive Assessment (MOCA), the Rey Auditory Verbal Learning Task-Revised (RAVLT-R), and the Logical Memory Subject of the Weschler Memory Scale. Several components of the RAVLT-R were evaluated including the Sum of Trials (Trials I-V) score, Proactive Interference Ratio (PI Ratio), and Retroactive Interference (RI Ratio).

Enrollment: 57 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Were 18 years of age or older

Exclusion criteria

• Were pregnant or breast-feeding
• Had been diagnosed with mental illness
• Didn't speak English fluently
• Had severe hearing problems
• Had recreational or opioid drug contaminants in their urine
• Were involved in criminal activity

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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57 participants in 2 patient groups, including a placebo group

Placebo, Then Cannabidiol

Placebo Comparator group

Description:

Participants first received a Placebo 246 mg press pill during visit 1. After a washout period of 1 week, subjects received a Cannabidiol press pill during visit 2.

Treatment:

Drug: Placebo (246mg press pill)

Cannabidiol, Then Placebo

Active Comparator group

Description:

Participants first received a Cannabidiol 246 mg press pill during visit 1. After a washout period of 1 week, subjects received a Placebo press pill during visit 2.

Treatment:

Drug: Cannabidiol (246mg press pill)