The Effect of Cannabis in Pancreatic Cancer

Jens Rikardt Andersen

Status and phase: Withdrawn; Phase 2

Conditions: Mortality; Neoplasms Pancreatic; Cannabis; Palliative Medicine; Appetite Loss; Cachexia; Cancer; Morbidity

Treatments: Drug: THC and CBD Mixture

Study type: Interventional

Funder types: Other

Identifiers

NCT03245658

H-17000277

Details and patient eligibility

About

Cannabinoids are known to increase appetite, but THC components have psychogenic properties too. CBD is the main component in the plant, and have only minimal psychogenic effects. The aim was to test the appetite stimulating effects of CBD in patients with pancreatic cancer in palliative treatment.

Full description

Randomization of consecutive patients who wanted to participate to a daily dose of CBD or not as a supplement to the standard treatment.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult, palliative pancreatic cancer diagnosis, weight loss > 5%, understand and read Danish.

Exclusion criteria

• Regular use of cannabis, psychiatric disorders, alcohol abuse, life expectancy < 6 months

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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0 participants in 2 patient groups

THC and CBD Mixture

Experimental group

Description:

32 patients with palliative pancreatic cancer, intervention with oral drops of THC, 25mg/ml and CBD 50mg/ml, daily administered for 4 weeks

Treatment:

Drug: THC and CBD Mixture

Control

No Intervention group

Description:

32 patients with palliative pancreatic cancer, no experimental treatment,