The Effect of Carotid IMT (Intima Media Thickness) on Postoperative Cognitive Dysfunction in Patients Undergoing Off-Pump Coronary Artery Bypass Graft Surgery

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Yonsei University

Status

Completed

Conditions

Coronary Artery Occlusive Disease

Study type

Observational

Funder types

Other

Identifiers

NCT02456493
4-2015-0254

Details and patient eligibility

About

The patients who have undergone cardiac surgery have higher likelihood of postoperative cognitive dysfunction (POCD). The carotid intima-media thickness (IMT) is associated with cognitive dysfunction in the old. The aim of this study is to evaluate the effect of carotid IMT in patients undergoing OPCAB(off-pump coronary artery bypass surgery) on postoperative cognitive dysfunction. Two hundred twenty four patients, aged 20 to 79 years, scheduled for OPCAB will be divided into increased IMT (n=112) and normal IMT (n=112) group by preoperative B-mode ultrasonography. The cognitive function measured by K-MMSE, MOCA-K before the operation, and on the 7 day, 3 months after operation. The patients in the non-surgical group are measured three times: baseline, after 7days, after 3 months.

Enrollment

224 patients

Sex

All

Ages

60+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

- patients who are scheduled to undergo OPCAB

Exclusion criteria

  • severe cognitive dysfunction
  • disabling mental change disorder
  • unable to communicate or speak Korean
  • do not have carotid IMT measurement.

Trial design

224 participants in 2 patient groups

increased carotid IMT group
Description:
Patients who have increased carotid IMT (intima media thickness)
normal carotid IMT group
Description:
Patients who have normal carotid IMT

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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