The Effect of Centralization on Medial Meniscal Extrusion for Medial Meniscus Posterior Root Tear Repair

Mayo Clinic

Status: Begins enrollment this month

Conditions: Meniscus Tear

Treatments: Procedure: Medial meniscus posterior root tear (MMPRT) repair without meniscus centralization; Procedure: Medial meniscus posterior root tear (MMPRT) repair with meniscus centralization

Study type: Interventional

Funder types: Other

Identifiers

NCT07388290

25-011455

Details and patient eligibility

About

The purpose of this research is to determine if meniscus root repair with or without centralization will have an impact on postoperative pain, function, activity levels, patient satisfaction, and incidence of revision meniscus surgery.

Enrollment: 54 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Type 2 Medial Meniscus Posterior Root Tear demonstrated on MRI
• Notable extrusion (>3 mm) on preoperative MRI
• Patient able to consent for themselves
• Patient agrees to comply with trial schedules and plan

Pre-operative Exclusion:

• Concomitant ligamentous or meniscal procedures
• Meniscal extrusion > 6 mm on pre-operative MRI
• Kellgren-Lawrence grade > 2
• Varus malalignment > 10 degrees
• Asymmetric varus alignment > 5 degrees
• Varus thrust while weightbearing
• Grade 3 bipolar medial compartment changes (isolated grade 3 changes on single articular surface with ≤ grade 2 changes on the opposing surface remains eligible)
• Previous surgery of the affected knee
• Associated fractures requiring surgery
• Concurrent Vascular injuries
• Hypermobility/Ehlers-Danlos Syndrome
• Inflammatory or autoimmune disease
• Severe mental/physical disability precluding post operative rehabilitation demands
• Contraindications to MRI
• Pregnant women

Arthroscopy Inclusion Criteria:

• Complete radial tears within 9 mm of medial meniscus posterior root
• ICRS Grade 3 or better

Arthroscopy Exclusion Criteria:

• Requiring concomitant procedures other than MMPRT
• ICRS Grade 4 changes

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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54 participants in 2 patient groups

Repair with meniscus centralization

Experimental group

Description:

Medial meniscus posterior root tear (MMPRT) surgical repair with meniscus centralization

Treatment:

Procedure: Medial meniscus posterior root tear (MMPRT) repair with meniscus centralization

Repair without centralization

Active Comparator group

Description:

Medial meniscus posterior root tear (MMPRT) surgical repair without centralization

Treatment:

Procedure: Medial meniscus posterior root tear (MMPRT) repair without meniscus centralization