The Effect of Chlorhexidine + Hyaluronic Acid on Postoperative Wound Healing After Lower Third Molar Removal

University of Pecs

Status

Not yet enrolling

Conditions

Dry Socket

Postoperative Infections

Treatments

Procedure: Third molar surgery

Study type

Interventional

Funder types

Other

Identifiers

NCT07044219

7613-PTE 2019.

Details and patient eligibility

About

Our aim is to evaluate chlorhexidine-hyaluronic acid containing gel on postoperative wound healing regarding impacted lower third molar surgery.

Full description

This is a triple-blind, placebo-controlled randomized clinical trial. Sixty patients will be randomly assigned to two treatment groups: Arm 1 receives Curasept DNA ADS periodontal gel during impacted third molar removal, while Arm 2 receives a placebo gel. Patient allocation uses an electronic randomization system with a 1:1 ratio. Baseline characteristics are recorded at the first clinical visit. The surgical procedure includes local anesthesia, mucoperiosteal flap elevation, bone removal with a surgical handpiece, and wound closure with non-resorbable sutures. Test gel or placebo is applied post-tooth removal, and patients are monitored postoperatively for pain, swelling, and wound healing, including follow-ups on the third, seventh and fourteenth days. Data analysis will use descriptive and statistical methods to evaluate efficacy.

Enrollment

60 estimated patients

Sex

All

Ages

18 to 99 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

patients having lower impacted third molar
impaction pattern Pell-Gregory II/A, III/A, I/B, II/B, III/B that means partially impacted, partially erupted teeth, where primary wound closure is usually not possible;

Exclusion criteria

systemic disease (diabetes, steroids, antiresorptive therapy);
allergy on gel's compounds;
pregnancy;
active or subacute local infection at third molar tooth (pericoronitis);
poor oral hygiene (based on the presence of active caries and/or plaque index of 2-3)