The Effect of Chloroquine in the Treatment of Patients With Dengue

University of Sao Paulo

Status and phase: Unknown; Phase 2; Phase 1

Conditions: Dengue

Treatments: Drug: Placebo; Drug: Chloroquine

Study type: Interventional

Funder types: Other

Identifiers

NCT00849602

BALF-01

Details and patient eligibility

About

The objective of this study was to evaluate the effect of chloroquine in the treatment of patients with dengue.

Enrollment: 132 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients suspected of having dengue disease

• Patients were included in the study if they presented with fever and at least two other symptoms, such as:

  • headache
  • pain behind the eyes
  • muscle and bone or joint pains
  • nausea
  • vomiting
  • rash associated to dengue for less than 72 hours

Exclusion criteria

• Pregnant
• Younger than 18-years old
• Either cardiac or neurologic disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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132 participants in 2 patient groups, including a placebo group

1

Placebo Comparator group

Treatment:

Drug: Placebo

2

Active Comparator group

Treatment:

Drug: Chloroquine