The Effect of Chocolate on Vascular Function of Endurance Runners

Aristotle University Of Thessaloniki

Status: Not yet enrolling

Conditions: Vascular Function

Treatments: Other: White chocolate Intervention; Other: Dark chocolate Intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT06440512

EC-161/2023

Details and patient eligibility

About

The aim of this study is to examine the effects of chocolate on the vascular function of endurance runners through a crossover study involving male runners consuming both dark and white chocolate.

Full description

Participants will be male endurance runners who will receive both black and white chocolate interventions. Arterial stiffness, cardiovascular parameters, respiratory parameters, and running performance will be assessed before and after each intervention period. The study will involve a two-week intervention period for each type of chocolate, with a washout period in between. The primary outcome measure will be arterial stiffness, while secondary outcome measures will include cardiovascular and respiratory parameters, as well as running performance. The study is expected to provide insights into the effects of chocolate consumption on vascular function in endurance athletes.

Enrollment: 50 estimated patients

Sex: Male

Ages: 25 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Gender: Male
• Age: 25-55 years
• Healthy status
• Active endurance runner
• Regular physical activity (at least 3 times per week)
• Availability on specific days and times for research sessions
• Willingness and consistency

Exclusion criteria

• Allergies or Intolerances: Participants with known allergies or intolerances to chocolate or any of its ingredients.
• Cardiovascular Diseases: Participants with known cardiovascular diseases or history of cardiac episodes.
• Metabolic Disorders: Individuals with diabetes or other metabolic disorders that may affect glucose and insulin metabolism.
• Contradictory Diet: Individuals following specific diets that may affect the study, such as high or low flavonoid diets.
• Medication Use: Individuals taking medications that affect vascular function, such as antihypertensives or anticoagulants.
• Smoking: Smokers or individuals who have quit smoking within the last six months.
• Substance Abuse: Individuals with a history of alcohol or substance abuse.
• Patients with Chronic Diseases: Individuals with serious chronic diseases that may affect the study outcomes.
• Participation in Other Studies: Individuals participating in other clinical trials or research that may affect the study outcomes.
• Physical Condition: Individuals who are not regular runners or who do not exercise regularly at a level similar to other participants.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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50 participants in 2 patient groups

A Chocolate Arm

Experimental group

Description:

Intervention period 1:The group will consume 50 grams of dark chocolate daily for two weeks. Washout period: Two-weeks Intervention period 2: The group will consume 40 grams of white chocolate daily for two weeks.

Treatment:

Other: Dark chocolate Intervention

Other: White chocolate Intervention

B Chocolate Arm

Experimental group

Description:

Intervention period 1:The group will consume 40 grams of white chocolate daily for two weeks. Washout period: Two-weeks Intervention period 2: The group will consume 50 grams of dark chocolate daily for two weeks

Treatment:

Other: Dark chocolate Intervention

Other: White chocolate Intervention