The Effect of Chronic Nitrate Supplementation on Acute Mountain Sickness and Exercise Performance in Hypoxia

Bangor University

Status: Completed

Conditions: Hypoxia

Treatments: Dietary Supplement: Beetroot Juice; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT03101904

Jan 27 2016

Details and patient eligibility

About

The study will aim to describe and evaluate the effect of chronic beetroot juice supplementation on acute mountain sickness symptoms and exercise in a hypoxic environment. It is hypothesized that beetroot supplementation will decrease acute mountain sickness and increase exercise performance.

Enrollment: 23 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Women only: Regular menstrual cycle or post-menopausal

Exclusion criteria

• Stayed at altitude above 2500m in the last 6 months
• Traveled to altitude above 2500m in the last 2 months
• Unable to give informed consent
• Unstable medical condition.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

---

23 participants in 2 patient groups, including a placebo group

Nitrate then Placebo

Experimental group

Description:

Participants will consume a daily a beetroot shot for six days. Each shot will consist of: 1x70ml concentrated NO-3 shot of rich Beetroot juice (\~7mmol nitrate; Beet It, James White Drinks Ltd, Ipswich, UK). Following a minimum of ten days wash out, participants will then consume a daily Nitrate-depleted beetroot shot for six days. Each shot will consist of 1x70ml nitrate-depleted beetroot Placebo shot (\~0.003mmol of nitrate; Beet It, James White Drinks Ltd, Ipswich, UK).

Treatment:

Dietary Supplement: Placebo

Dietary Supplement: Beetroot Juice

Placebo then Nitrate

Placebo Comparator group

Description:

Participants will consume a daily Nitrate-depleted beetroot shot for six days. Each shot will consist of 1x70ml nitrate-depleted beetroot Placebo shot (\~0.003mmol of nitrate; Beet It, James White Drinks Ltd, Ipswich, UK). Following a minimum of ten days wash out, participants will then consume a daily beetroot shot for six days. Each shot will consist of: 1x70ml concentrated NO-3 shot of rich Beetroot juice (\~7mmol nitrate; Beet It, James White Drinks Ltd, Ipswich, UK).

Treatment:

Dietary Supplement: Placebo

Dietary Supplement: Beetroot Juice