The Effect of Citrus Extract on Oxidative Stress

Maastricht University Medical Centre (MUMC)

Status

Completed

Conditions

Elderly

Treatments

Dietary Supplement: Citrus extract

Dietary Supplement: Placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT03580447

183018

Details and patient eligibility

About

This randomized, cross-over, double-blind, placebo-controlled trial aims to determine the effects of daily administration of citrus extract over a period of 4 weeks on markers of oxidative stress in elderly.

Enrollment

37 patients

Sex

All

Ages

70 to 85 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy individuals
Age 70-85 years
BMI < 30 kg/m2

Exclusion criteria

History or actual status of severe cardiovascular, respiratory, urogenital, gastrointestinal/ hepatic, hematological/immunologic, HEENT (head, ears, eyes, nose, throat), dermatological/connective tissue, musculoskeletal, metabolic/nutritional, endocrine, neurological diseases, major surgery and/or laboratory assessments which might limit participation in or completion of the study protocol.
Disease with a life expectancy shorter than 5 years
Institutionalized (e.g. hospital or nursing home).
Subjects with abnormalities in haematology which may interfere with the endpoints of the study (to be decided by the principle investigator)
Use of drugs or hormones within 3 months prior to the start of the study which may interfere with the endpoints of the study (to be decided by the principle investigator)
Self-admitted Inflammation, (viral) infection (e.g. HIV or hepatitis B)
Subjects with an autoimmune disease (e.g. Rheumatoid arthritis)
Subjects with intestinal disorders which may interfere with the endpoints of the study (to be decided by the principle investigator)
Use of immunosuppressive drugs within 3 months prior to the start of the study
Use of medication (e.g. NSAIDs), antibiotics or corticosteroids which may interfere with the endpoints of the study (to be decided by the principle investigator)
Changes in medication that may significantly affect the study outcome (according to the investigator's judgment) within 1 month prior to the start of the study.
Use of investigational drugs or participation in any scientific intervention study which may interfere with this study (to be decided by the principle investigator) in the 180 days before the study
Use of (dietary) supplements containing antioxidants, vitamins and minerals
Smoking
Weight gain or loss (> 3 kg in the previous 3 months)
Excessive intake of foods with a high polyphenol concentration
Use of pre-, pro or synbiotics within 1 month prior to the start of the study
Blood donation within 1 month prior to the start of the study
Excessive alcohol consumption (>20 alcoholic consumptions per week)
History of any side effects towards the intake of flavonoids or citrus fruits