The Effect of Clopidogrel on Coated-Platelets in Patients Undergoing Cardiac Catheterization

University of Oklahoma (OU)

Status: Completed

Conditions: Coronary Artery Disease; Chest Pain

Treatments: Drug: Clopidogrel

Study type: Interventional

Funder types: Other

Identifiers

NCT00644657

13291

Details and patient eligibility

About

This study will explore the effect of clopidogrel on coated-platelets in patients who are given a loading dose before diagnostic catheterization or percutaneous coronary intervention. We hypothesis that clopidogrel will reduce the percentage of platelets that are coated and therefore more hypercoagulable.

Full description

Platelet activity will be determined by light transmission aggregometry at baseline, after a 300 mg dose of clopidogrel and after the catheterization and/or angioplasty procedure. The change in the percentage of platelets that are coated platelets will be determined.

Enrollment: 27 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients given clopidogrel loading dose before scheduled catheterization or percutaneous intervention

Exclusion criteria

• Acute coronary syndrome
• Unable to tolerate clopidogrel

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)