The Effect of Cocoa on Platelet Function Profiles in Patients (ECLAIR)

The University of The West Indies

Status: Completed

Conditions: Platelet Dysfunction

Treatments: Dietary Supplement: Cocoa

Study type: Interventional

Funder types: Other

Identifiers

NCT04554901

CREC-SA.0351/05/2020

Details and patient eligibility

About

The effects of chocolate on cardiovascular health are still a matter of debate. It can potentially favor cardiovascular health through the antioxidative effects of cocoa ingredients, such as polyphenols (present in dark but not white chocolate).

Full description

Epidemiologic studies have shown inverse associations between dietary polyphenols (present in dark chocolate and cocoa) and mortality from coronary heart disease. However, the basis for this protective association is uncertain. Food polyphenols such as in cocoa reportedly have antioxidant properties and decrease platelet function in vitro. The goal of the present study was to investigate whether the beneficial antioxidant effect of polyphenol-rich cocoa can induce an improvement of endothelial and platelet function in patients with stable coronary artery disease with known platelet hyperreactivity.

Enrollment: 25 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Patients with stable coronary artery disease.
2. Patients > 18y of age.

Exclusion criteria

1. Patients with T2DM.
2. Patients who already ingest any cocoa-based products.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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25 participants in 1 patient group

Cocoa

Other group

Description:

2-week, once-daily 70%, 50g cocoa bar manufactured by The UWI Cocoa Research Institute (14 bars)

Treatment:

Dietary Supplement: Cocoa