The Effect of Coenzyme Q10 in Preventing Pain After Thoracoscopic Surgery

Chongqing Medical University

Status and phase: Enrolling; Phase 4

Conditions: Postoperative Pain

Treatments: Other: Placebo; Drug: Coenzyme Q10

Study type: Interventional

Funder types: Other

Identifiers

NCT06743802

Coenzyme Q10 and pain

Details and patient eligibility

About

This study aimed to assess the effectiveness of Coenzyme Q10 in preventing both acute and chronic pain following thoracoscopic surgery, with a focus on its potential benefits in reducing the incidence and severity of pain.

Enrollment: 264 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged 18-75 years;
• American Society of Anesthesiology (ASA) physical status classification I-III;
• Scheduled for elective lung resection surgery under thoracoscopy;
• Voluntarily opting for patient-controlled intravenous analgesia;
• Willing to participate in this trial after consultation with the patient or their family and signing the informed consent form.

Exclusion criteria

• History of previous thoracotomy or thoracoscopic surgery;
• Patients converted to open thoracotomy intraoperatively;
• Severe hepatic or renal dysfunction;
• History of substance abuse;
• Pregnancy or breastfeeding;
• History of chronic pain;
• Use of coenzyme Q10 for more than one month;
• Allergy to coenzyme Q10;
• Patients unable to communicate or cooperate.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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264 participants in 2 patient groups, including a placebo group

Coenzyme Q10

Experimental group

Treatment:

Drug: Coenzyme Q10

Placebo

Placebo Comparator group

Treatment:

Other: Placebo