the Effect of coenzymeq10/Collagen Hydrogel on Bone Regeneration in Extraction Socket

Hams Hamed Abdelrahman

Status: Completed

Conditions: Dental Implants

Treatments: Procedure: Study group; Procedure: Negative control group; Procedure: Postive control

Study type: Interventional

Funder types: Other

Identifiers

NCT05122299

implants_20_21

Details and patient eligibility

About

To investigate the effect of CoQ10 in soft tissue healing and bone regeneration after extraction in diabetic patients seeking dental implants. Methods: This study will be a randomized controlled clinical trial, 18 patients will be divided equally into three groups. In-vitro studies will be performed to investigate the release of CoQ10 from collagen, swelling ratio, and evaluation of gelation behavior. The patients will undergo tooth extraction and filling of the socket with either collagen or CoQ10/collagen. Empty sockets will serve as a negative control. The bone regeneration of the socket will be determined by radiography, histology, histomorphometry, and polymerase chain reaction (PCR) for bone markers.

Enrollment: 18 patients

Sex: All

Ages: 30 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 30-60 years including both males and females .
• Controlled Type II diabetic patients glycosylated hemoglobin (HbA1C) levels less than 7
• Good oral hygiene
• No history of bruxism/ para-functional habits
• Patients accept to sign the informed consent .
• Single or multiple Mandibular teeth requiring extraction.

Exclusion criteria

• Uncontrolled diseases that may contraindicate the surgery.
• Somkers patients.
• Osteoporosis.
• Hypersensitivity.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

18 participants in 3 patient groups

Negative control group

Other group

Treatment:

Procedure: Negative control group

Positive control group

Active Comparator group

Treatment:

Procedure: Postive control

Study group

Experimental group

Treatment:

Procedure: Study group