The Effect of Coffee Consumption on the Serum Levels of Leptin, Folic Acid, and Vitamin B12

Applied Science Private University

Status: Unknown

Conditions: Atherosclerosis

Treatments: Behavioral: Normal BMI and heavy coffee consumption; Behavioral: overweight and heavy coffee consumption; Behavioral: overweight and moderate coffee consumption; Behavioral: Normal BMI and moderate coffee consumption

Study type: Observational

Funder types: Other

Identifiers

NCT04488731

2020-PHA-19

Details and patient eligibility

About

The effect of coffee and body weight during the last 3 months on the level of leptin, folic acid, and vitamin B12

Full description

Coffee consumption has been associated with several risk factors leading to cardiovascular diseases (CVDs), including hyperhomocysteinemia and hyperlipidemia. Frequent coffee consumption has beneficial effects in reducing the risk of diabetes mellitus (DM) type 2, obesity, liver disease, CVDs, some types of cancer, Parkinson's disease, and Alzheimer's disease. Controversies concerning coffee consumption benefits and risks in regards for CVDs were mentioned in many studies. Folic acid and vitamin B12 are necessary vitamins in homocysteine metabolism which is a risk factor for atherosclerosis. Leptin, is a hormone linked to obesity and it could be related to atherosclerosis.

The combined effect of coffee consumption and body weight on the levels of leptin, folic aid, and vitamin B12 is not well studied. In our study, we will study the effect of coffee consumption in males with different body mass indices to see the effect of several important parameters such as leptin, Folic acid, and vitamin B12.

Enrollment: 120 estimated patients

Sex: Male

Ages: 18 to 26 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• male,
• ASU student,
• do not have any acute or chronic medical conditions.

Exclusion criteria

• students who used any medications for either an acute and/or a chronic condition during the past 3 months prior to the study entry.

Trial design

120 participants in 4 patient groups

NW/MCC

Description:

Normal body mass index (BMI) / with moderate coffee consumption

Treatment:

Behavioral: Normal BMI and moderate coffee consumption

NW/HCC

Description:

Normal body mass index (BMI) / with heavy coffee consumption

Treatment:

Behavioral: Normal BMI and heavy coffee consumption

OW/MCC

Description:

Overweight / with moderate coffee consumption

Treatment:

Behavioral: overweight and moderate coffee consumption

OW/HCC

Description:

Overweight / with heavy coffee consumption

Treatment:

Behavioral: overweight and heavy coffee consumption