The Effect of Coffee on Energy Expenditure and Caffeine Metabolism

Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences

Status: Enrolling

Conditions: Healthy

Treatments: Other: Caffeine content

Study type: Interventional

Funder types: Other

Identifiers

NCT06712511

SIAT IRB 240715H0902

Details and patient eligibility

About

Obesity is a risk factor for chronic diseases, and improving energy expenditure is a way to prevent and treat obesity. The purpose of this project is to explore the relationship between the effect of coffee on energy expenditure and caffeine metabolism, which has important significance in the rational application of caffeine.

Full description

The investigators will study the relationship between the effect of coffee on energy expenditure and caffeine metabolism. The investigators will recruit healthy participants. Participants will be forbidden to consume stimulant drinks such as coffee for 24 hours before the experiment. When the participants arrive at the lab on the day of the experiment, they will sign an informed consent form, a health history questionnaire and a daily coffee consumption questionnaire. The changes of drinking water/coffee on total energy expenditure (TEE), body temperature, heart rate, blood pressure, electrocardiogram, memory，cognition, sleep time and so on will be observed. The concentration of caffeine and its metabolites in the blood and urine will be measured by liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS).

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria：

• Healthy adults.
• Must be able to drink coffee.

Exclusion Criteria:

• Diabetes.
• Hypoglycemia.
• Gout.
• Osteoporosis.
• Gastric ulcer.
• Pancreatitis.
• Intestinal obstruction.
• Blood phobia.
• Pathological hypo or hyper tension.
• Impaired glucose tolerance.
• Claustrophobia.
• HIV,etc.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups

water

Experimental group

Description:

The participants will drink 200 ml water four times at 1 hour intervals.

Treatment:

Other: Caffeine content

coffee

Experimental group

Description:

The participants will drink 200 ml coffee four times at 1 hour intervals.

Treatment:

Other: Caffeine content