The Effect of Cognitive Functions on Upper Extremity Functionality in Parkinson's Patients

Pamukkale University

Status: Completed

Conditions: Functional Disturbance; Cognitive Impairment; Upper Extremity Problem; Parkinson

Treatments: Diagnostic Test: clinical assessment

Study type: Interventional

Funder types: Other

Identifiers

NCT05872646

PamukkaleU-sımsek-parkınson-01

Details and patient eligibility

About

Parkinson's Disease (PD), first described by James Parkinson in 1817, is a progressive movement disorder that develops mainly as a result of the destruction of nigrostriatal dopaminergic neurons. The aim of our study is to determine the effect of cognitive functions on upper extremity functionality in individuals with Parkinson's Disease.

Full description

Parkinson's Disease (PD), first described by James Parkinson in 1817, is a progressive movement disorder that develops mainly as a result of the destruction of nigrostriatal dopaminergic neurons. Involvement of nigrostriatal dopaminergic neurons is associated with the motor manifestations of the disease. The most common of these symptoms are; resting tremor, bradykinesia, rigidity and balance disorder. However, non-motor symptoms related to the involvement of nervous system structures other than the dopaminergic nigrostriatal system can be observed in PD. However, due to the predominance of motor symptoms in PD, it took many years to notice cognitive changes. Traditionally, cognitive impairments in PD have been expected to occur in the advanced stages of the disease. However, cognitive impairments in the early stages are reported in approximately 30-35% of patients. Cognitive dysfunction is defined in PD, ranging from mild impairments in certain cognitive domains to severe dementia. Cognitive impairment primarily affects executive and visuospatial functions, and memory is secondarily affected.

Executive functions are higher cognitive processes that use and modify information from many cortical sensory systems in the fore and hindbrain areas to modulate and teach behavior. The frontal cortex, especially the prefrontal cortex and its striatal connections are very important neuroanatomical regions for executive functions. The relationship between the effects of cognition and motor performance and parameters in groups such as the elderly, PD and Alzheimer's patients in which these centers are affected has been an issue that has attracted the attention of many researchers. Most of the studies have focused on the lower extremity performance of cognition. However , it has been reported that cognition has positive effects on upper extremity performance and early acquired upper extremity skills have positive effects on cognitive performance .

The aim of our study is to determine the effect of cognitive functions on upper extremity functionality in individuals with Parkinson's Disease.

Enrollment: 104 patients

Sex: All

Ages: 30 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Having a diagnosis of Parkinson's Disease.
• Not having hearing and vision problems.
• To be able to take the commands required for the manual dexterity tests.
• Agree to participate in the study.

Exclusion criteria

• Having undergone musculoskeletal surgery for the upper extremity.
• Having vision and hearing problems.
• Having an additional disease that may affect cognitive tests.

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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104 participants in 2 patient groups

patient group

Experimental group

Description:

parkınson patient group

Treatment:

Diagnostic Test: clinical assessment

healthy group

Other group

Description:

age-gender matched healthy group

Treatment:

Diagnostic Test: clinical assessment